Mecamylamine hydrochloride

Cat. No. 2843

Mecamylamine hydrochloride C11H21N.HCl [826-39-1]

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Chemical Name: N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

Biological Activity

Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.

Technical Data

M.Wt:
203.75
Formula:
C11H21N.HCl
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Storage:
Desiccate at RT
CAS No:
826-39-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Ostroumov et al (2007) Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 37 393. PMID: 17938901.

Rabenstein et al (2006) The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol. 189 395.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:

Stouffer et al (2015) Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543. PMID: 26503322.

Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843. PMID: 24513971.

Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155. PMID: 21544206.

Zhang et al (2011) Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem 286 25331. PMID: 21610071.

Do you know of a great paper that uses Mecamylamine hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Mecamylamine hydrochloride, supplier, Non-competitive, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products

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