Cat. No. 2843
Chemical Name: N,2,3,3-Tetramethylbicyclo[2.2.1]he
Biological ActivityNon-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ostroumov et al (2007) Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 37 393. PMID: 17938901.
Rabenstein et al (2006) The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol. 189 395.
If you know of a relevant reference for Mecamylamine hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:
Herman et al (2016) A cholinergic basal forebrain feeding circuit modulates appetite suppression Nature 538 253. PMID: 27698417.
Kam et al (2016) Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology. Proc Natl Acad Sci U S A 6 20119. PMID: 26818394.
Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission Scientific Reports 6 37834. PMID: 27886263.
Bryant et al (2015) Cholinergic control of γ power in the midbrain spatial attention network. Elife 35 761. PMID: 25589769.
Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. PLoS One 9 6. PMID: 25709566.
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Eur J Neurosci 10 e0131430. PMID: 26102354.
Leão et al (2015) Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca. J Neurosci 113 971. PMID: 25392162.
Liu et al (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. Front Cell Neurosci 35 5680. PMID: 25855181.
Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Sci Rep 4. PMID: 25723967.
Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. J Neurophysiol 112 8124. PMID: 26080439.
Stouffer et al (2015) Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543. PMID: 26503322.
Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843. PMID: 24513971.
Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155. PMID: 21544206.
Zhang et al (2011) Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem 286 25331. PMID: 21610071.
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Keywords: Mecamylamine hydrochloride, supplier, Non-competitive, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products
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Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
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