Cat. No. 2843
Chemical Name: N,2,3,3-Tetramethylbicyclo[2.2.1]he
Biological ActivityNon-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ostroumov et al (2007) Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 37 393. PMID: 17938901.
Rabenstein et al (2006) The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol. 189 395.
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Citations are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:
Stouffer et al (2015) Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543. PMID: 26503322.
Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843. PMID: 24513971.
Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155. PMID: 21544206.
Zhang et al (2011) Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem 286 25331. PMID: 21610071.
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Keywords: Mecamylamine hydrochloride, supplier, Non-competitive, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products
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