LY 344864 hydrochloride
Cat. No. 2451
Chemical Name: N-[(3R)-3-(Dimethylamino)-2,3,4,9-t
Biological ActivityPotent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.
Licensing InformationSold under license from Eli Lilly and Company
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Goadsby and Classey (2003) Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input. Neuroscience 122 491. PMID: 14614913.
Ramadan et al (2003) 5-HT1F receptor agonists in acute migraine treatment: a hypothesis. Cephalalgia 23 776. PMID: 14510923.
Lee et al (1997) Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Science 61 2117.
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Citations are publications that use Tocris products. Selected citations for LY 344864 hydrochloride include:
Garrett et al (2014) Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther 350 257. PMID: 24849926.
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