PD 118057

Cat. No. 2830

PD 118057 C21H17Cl2NO2 [313674-97-4]

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Chemical Name: 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid

Biological Activity

Human ether-a-go-go (hERG) KV11.1 potassium channel activator. Displays no major effect on INa, ICa/L, IK1 and IKs currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro.

Technical Data

M.Wt:
386.27
Formula:
C21H17Cl2NO2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
313674-97-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Duff (2008) hERG: The long and short of it. Heart Rhythm 5 591. PMID: 18362028.

Yeung and Greenwood (2007) Pharmacological and biophysical isolation of K+ currents encoded by ether-a-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am.J.Physiol.Cell.Physiol. 292 C468. PMID: 16870833.

Zhou et al (2005) Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol.Pharmacol. 68 876. PMID: 15976038.

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Keywords: PD 118057, supplier, Human, ether-a-go-go, hERG, K+, potassium, KV, channels, activators, voltage-gated, voltage-dependent, PD118057, KV11.1, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products

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