α-Estradiol

Cat. No. 2823

a-Estradiol C18H24O2 [57-91-0]

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Chemical Name: (17α)-Estra-1,3,5(10)-triene-3,17-diol

Biological Activity

Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively). β-Estradiol (Cat. No. 2824) also available.

Technical Data

M.Wt:
272.38
Formula:
C18H24O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>96 %
Storage:
Store at RT
CAS No:
57-91-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Toran-Allerand et al (2002) ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J.Neurosci. 22 8391. PMID: 12351713.

Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138 863. PMID: 9048584.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for α-Estradiol include:

Dexter et al (2015) Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae. Sci Rep 9 17. PMID: 25888817.

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.

McIsaac et al (2012) Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway. Mol Biol Cell 23 2993. PMID: 22696683.

Do you know of a great paper that uses α-Estradiol from Tocris? If so please let us know.

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Keywords: a-Estradiol, supplier, Endogenous, estrogen, receptor, agonists, ER, Estrogen, Receptors, α-Estradiol, alpha-Estradiol, a-estradiol, Tocris Bioscience, Estrogen and Related Receptor Agonist products

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