Valproic acid, sodium salt
Cat. No. 2815
Alternative Names: VPA, Sodium Valproate
Chemical Name: Sodium 2-propylpentanoate
Biological ActivityHistone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Huangfu et al (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 26 1269. PMID: 18849973.
Qing et al (2008) Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 205 2781. PMID: 18955571.
Kim et al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 321 892. PMID: 17371805.
Kostrouchova et al (2007) Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 53 37. PMID: 17448293.
Phiel et al (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276 36734. PMID: 11473107.
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Citations are publications that use Tocris products. Selected citations for Valproic acid, sodium salt include:
Chen et al (2015) Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition. Nat Commun 35 339. PMID: 25568126.
Wang et al (2014) The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. Cancer Biol Ther 15 1198. PMID: 24919179.
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