Cat. No. 1599
Biological ActivityInhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluR2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluR2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3. PMID: 12941441.
Hanley et al (2002) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Neuron 34 53. PMID: 11931741.
Daw et al (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 28 873. PMID: 11163273.
Li et al (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 2 972. PMID: 10526335.
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Citations are publications that use Tocris products. Selected citations for pep2-EVKI include:
Dickinson et al (2009) A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha. Mol Brain 2 18. PMID: 19534762.
Yao et al (2008) PKM ζ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. Proc Natl Acad Sci U S A 28 7820. PMID: 18667614.
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Keywords: pep2-EVKI, supplier, Peptide, inhibitors, inhibits, GluR2, subunit, binding, PICK1, Glutamate, AMPA, Receptors, iGluR, Ionotropic, Tocris Bioscience, AMPA Receptor Inhibitor products
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