Cat. No. 1597
Biological ActivityInhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluR2 AMPA receptor subunit. Disrupts binding of GluR2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). Control peptide available (Cat. No. 1597).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3. PMID: 12941441.
Kim et al (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 98 11725. PMID: 11573007.
Daw et al (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 28 873. PMID: 11163273.
Li et al (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 2 972. PMID: 10526335.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for pep2-SVKI include:
McElligott et al (2010) Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. J Neurosci 107 2271. PMID: 20133871.
Dickinson et al (2009) A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha. Mol Brain 2 18. PMID: 19534762.
Xia et al (2007) Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci 27 12221. PMID: 17989288.
Do you know of a great paper that uses pep2-SVKI from Tocris? If so please let us know.
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Keywords: pep2-SVKI, supplier, Peptide, inhibitors, inhibits, GluR2, subunit, binding, GRIP, ABP, PICK1, Increases, AMPA, current, amplitude, Glutamate, Receptors, iGlur, Ionotropic, Tocris Bioscience, AMPA Receptor Inhibitor products
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