pep2m

Cat. No. 1595

pep2m Lys-Arg-Met-Lys-Val-Ala-Lys-Asn-Ala-Gln

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Alternative Names: GluR2m, G10

Biological Activity

Peptide inhibitor of the interaction between the C-terminus of the GluR2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression. Control peptide pep4c (Cat. No. 1596) also available.

Technical Data

M.Wt:
1173.44
Formula:
C49H92N18O13S
Sequence:
KRMKVAKNAQ
Solubility:
Soluble to 2 mg/ml in 20% acetonitrile
Storage:
Desiccate at -20°C
CAS No:
243843-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3. PMID: 12941441.

Luscher et al (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24 649. PMID: 10595516.

Luthi et al (1999) Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron 24 389. PMID: 10571232.

Noel et al (1999) Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron 23 365. PMID: 10399941.

Nishimune et al (1998) NSF binding to GluR2 regulates synaptic transmission. Neuron 21 87. PMID: 9697854.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for pep2m include:

Yao et al (2008) PKM ζ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. Proc Natl Acad Sci U S A 28 7820. PMID: 18667614.

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Keywords: pep2m, supplier, Peptide, inhibitors, inhibits, GluR2, subunit, binding, NSF, N-ethylmaleimide-sensitive, fusion, protein, Reduces, AMPA, currents, Glutamate, Receptors, iGlur, Ionotropic, Tocris Bioscience, AMPA Receptor Inhibitor products

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