Cat. No. 2838
Chemical Name: (R)-(-)-1-(3-Hydroxyphenyl)-2-methy
Biological Activityα1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Morton et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112. PMID: 17115072.
Ford et al (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 121 1127. PMID: 9249248.
Minneman et al (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 46 929. PMID: 7969082.
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Citations are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:
Jin et al (2015) Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus. J Neurosci 10 e0126956. PMID: 25962147.
Lam et al (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. PLoS One 13 584. PMID: 21531340.
Do you know of a great paper that uses (R)-(-)-Phenylephrine hydrochloride from Tocris? If so please let us know.
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Keywords: (R)-(-)-Phenylephrine hydrochloride, supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, agonists, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, Tocris Bioscience, Adrenergic α1 Receptor Agonist products
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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