Cat. No. 2816
Chemical Name: (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihy
Biological ActivitySteroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kaileh et al (2007) Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity. J.Biol.Chem. 282 4253. PMID: 17150968.
Yang et al (2007) The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian Winter Cherry". Mol.Pharmacol. 71 426. PMID: 17093135.
Mohan et al (2004) Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 7 115. PMID: 15516832.
If you know of a relevant reference for Withaferin A please let us know.
Citations are publications that use Tocris products. Selected citations for Withaferin A include:
Yang et al (2016) The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Neural Plast 7 11385. PMID: 27150562.
Martorana et al (2015) Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes. EMBO J 2015 381964. PMID: 26266054.
Trendelenburg et al (2012) TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A. Skelet Muscle 2 3. PMID: 22313861.
Yadav et al (2010) Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J Mol Med (Berl) 88 1243. PMID: 20798912.
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Keywords: Withaferin A, supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, WithaferinA, Tocris Bioscience, NF-κB and IκB Inhibitor products
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