TM 5441

Cat. No. 6194new

TM 5441 C21H16ClN2NaO6

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Chemical Name: 5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt

Biological Activity

Plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 3.58 - 60.3 μM). Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and cardiac hypertrophy in mice. Renoprotective. Orally bioavailable.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jeong et al (2016) Novel plasminogen activator inhibitor-1 inhibitors prevent diabetic kidney injury in a mouse model. PLoS One. 11. PMID: 27258009 .

Placencio et al (2015) Small molecule inhibitors of plasminogen activator inhibitor-1 elicit anti-tumorigenic and anti-angiogenic activity. PLoS One. 10. PMID: 26207899.

Eren et al (2014) PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc.Natl.Acad.Sci.USA. 111 7090. PMID: 24778222 .

Boe et al (2013) Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Circulation. 128 2318. PMID: 24092817.

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Citations are publications that use Tocris products.

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Keywords: TM 5441, supplier, TM5441, PAI-1, inhibitor, inhibits, cancer, apoptosis, senescence, ageing, blood, pressure, telomere, hypertrophy, renoprotective, orally, bioavailable, Tocris Bioscience, Other Protease Inhibitor products

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