Arachidonyl serotonin

Cat. No. 2836

Arachidonyl serotonin C30H42N2O2 [187947-37-1]

Price and Availability

For Arachidonyl serotonin pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: AA-5-HT

Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide

Biological Activity

Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

Technical Data

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Maione et al (2007) Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 150 766. PMID: 17279090.

Di Marzo et al (2004) The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 3 771. PMID: 15340387.

Bisogno et al (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms. 248 515.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Arachidonyl serotonin from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Arachidonyl serotonin, supplier, Dual, FAAH, inhibitors, inhibits, TRPV1, antagonists, cannabinoids, Receptors, Vanillioid, VR1, Channels, Transient, Receptor, Potential, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, AA5HT, Tocris Bioscience, Other Cannabinoid products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Cannabinoid Review

Written by Roger Pertwee

Cannabinoid Receptor Ligands Scientific Review

Our Cannabinoid review gives an overview of the pharmacological ligands used to study the cannabinoid CB1 and CB2 receptors. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.