Sodium orthovanadate

Cat. No. 2821

Sodium orthovanadate Na3O4V [13721-39-6]

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Chemical Name: Trisodium vanadate

Biological Activity

Inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases. Suppresses p53-mediated apoptosis by transcription-dependent and -independent pathways.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Morita et al (2010) Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res. 70 257. PMID: 20048077.

Hasegawa et al (2006) Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats. J.Pharmacol.Exp.Ther. 317 875. PMID: 16461588.

Matsumoto et al (2006) Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia. J.Pharmacol.Exp.Ther. 318 982. PMID: 16782823.

Ai et al (2004) Inhibition of small-intestinal sugar absorption mediated by sodium orthovanadate Na3VO4 in rats and its mechanisms. World J.Gastroenterol. 10 3612. PMID: 15534916.

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Keywords: Sodium orthovanadate, supplier, Protein, tyrosine, phosphatase, inhibitors, PTP, Shp1, Shp2, Tyrosine, Phosphatases, inhibits, ATPases, inhibitor, alkaline, phosphatases, Tocris Bioscience, Protein Tyrosine Phosphatases Inhibitor products

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