(+)-Tubocurarine chloride

Cat. No. 2820

(+)-Tubocurarine chloride C37H41ClN2O6.HCl [57-94-3]

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Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride

Biological Activity

Competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.

Technical Data

M.Wt:
681.65
Formula:
C37H41ClN2O6.HCl
Solubility:
Soluble to 25 mM in water and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
57-94-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wotring and Yoon (1995) The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci. 67 293.

Pederson and Cohen (1990) d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA 87 2785.

Peters et al (1990) Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts. 110 107.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:

Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. BMC Syst Biol 9 30. PMID: 25717295.

Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701. PMID: 26134652.

Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Front Behav Neurosci 110 103. PMID: 23576702.

Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Biol Chem 31 2937. PMID: 22531784.

Lamy et al (2010) Allosteric block of KCa2 channels by apamin. J Neurophysiol 285 27067. PMID: 20562108.

Do you know of a great paper that uses (+)-Tubocurarine chloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (+)-Tubocurarine chloride, supplier, Nicotinic, receptor, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, curare, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products

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