Cat. No. 2820
Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-
Biological ActivityCompetitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wotring and Yoon (1995) The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci. 67 293.
Pederson and Cohen (1990) d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA 87 2785.
Peters et al (1990) Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts. 110 107.
If you know of a relevant reference for (+)-Tubocurarine chloride please let us know.
Citations are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. BMC Syst Biol 9 30. PMID: 25717295.
Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701. PMID: 26134652.
Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Front Behav Neurosci 110 103. PMID: 23576702.
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Keywords: (+)-Tubocurarine chloride, supplier, Nicotinic, receptor, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, curare, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products
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