PP 3

Cat. No. 2794

PP 3 C11H9N5 [5334-30-5]

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Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Negative control for the Src kinase inhibitor PP 2 (Cat. No. 1407). Inhibits EGFR kinase (IC50 = 2.7 μM).

Technical Data

M.Wt:
211.22
Formula:
C11H9N5
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
5334-30-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Hou et al (2007) PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 420 235.

Traxler et al (1997) Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 40 3601. PMID: 9357527.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PP 3 include:

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316. PMID: 25181481.

Do you know of a great paper that uses PP 3 from Tocris? If so please let us know.

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Keywords: PP 3, supplier, Negative, control, PP, 2, EGFR-kinases, inhibitors, Src, negative, Epidermal, Growth, Factors, Receptors, ErbB, Her, EGFR, Receptor, Tyrosine, RTKs, PP3, Tocris Bioscience, EGFR Inhibitor products

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