Cat. No. 2794
Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidi
Biological ActivityNegative control for the Src kinase inhibitor PP 2 (Cat. No. 1407). Inhibits EGFR kinase (IC50 = 2.7 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hou et al (2007) PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 420 235.
Traxler et al (1997) Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 40 3601. PMID: 9357527.
If you know of a relevant reference for PP 3 please let us know.
Citations are publications that use Tocris products. Selected citations for PP 3 include:
Vijayakumar et al (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Neural Regen Res 128 251. PMID: 25413351.
Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316. PMID: 25181481.
Kupferman et al (2014) Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. J Neuroimmune Pharmacol 158 1335. PMID: 25201528.
Rosas et al (2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Cell 9 2164. PMID: 25657738.
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Keywords: PP 3, supplier, Negative, control, PP, 2, EGFR-kinases, inhibitors, inhibits, Src, negative, Epidermal, Growth, Factors, Receptors, ErbB, Her, EGFR, Receptor, Tyrosine, RTKs, PP3, Tocris Bioscience, EGFR Inhibitor products