Sauvagine

Cat. No. 1609

Sauvagine Glp-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2

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Biological Activity

Corticotropin-releasing factor (CRF) receptor agonist. Ki values are 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b respectively.

Technical Data

M.Wt:
4599.35
Formula:
C202H346N56O63S
Sequence:
XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI

(Modifications: X-1 = Glp, Ile-40 = C-terminal amide)

Storage:
Desiccate at -20°C
CAS No:
74434-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Eckart et al (1999) Actions of CRF and its analogues. Curr.Med.Chem. 6 1035. PMID: 10519912.

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. PMID: 10816663.

Montecucchi and Henschen (1981) Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of PHYLLOMEDUSA SAWAGEI. Int.J.Pept.Protein Res. 18 113. PMID: 7309372.

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Keywords: Sauvagine, supplier, CRF, agonists, Corticotropin-Releasing, Factor, Non-Selective, Receptors, Tocris Bioscience, Non-selective CRF Receptor Agonist products

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