DPPI 1c hydrochloride

Cat. No. 2783

DPPI 1c hydrochloride C14H20N4O2.HCl [866396-70-5]

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Chemical Name: 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride

Biological Activity

Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50 > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

Technical Data

M.Wt:
312.8
Formula:
C14H20N4O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in water
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
866396-70-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wright et al (2006) cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J.Med.Chem. 49 3068. PMID: 16722626.

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Keywords: DPPI 1c hydrochloride, supplier, Dipeptidyl, peptidase, IV, DPP-IV, inhibitors, inhibits, Peptidase, Proteinases, Proteases, DPPI1c, hydrochloride, Tocris Bioscience, Dipeptidyl Peptidase IV Inhibitor products

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