Acetyl-Calpastatin (184-210) (human)
Cat. No. 2950
Biological ActivitySelective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70.
Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377.
Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866. PMID: 2553724.
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Citations are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:
Davis et al (2016) Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. Hypertension 1 e86355. PMID: 27158675.
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