Acetyl-Calpastatin (184-210) (human)

Cat. No. 2950

Acetyl-calpastatin 184-210 (human) Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

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Biological Activity

Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data

M.Wt:
3177.65
Formula:
C142H230N36O44S
Sequence:
DPMSSTYIEELGKREVTIPPKYRELLA

(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
123714-50-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70.

Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377.

Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866. PMID: 2553724.

If you know of a relevant reference for Acetyl-Calpastatin (184-210) (human) please let us know.

Citations are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:

Davis et al (2016) Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. Hypertension 1 e86355. PMID: 27158675.

Do you know of a great paper that uses Acetyl-Calpastatin (184-210) (human) from Tocris? If so please let us know.

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Keywords: Acetyl-calpastatin 184-210 (human), supplier, Selective, calpain, inhibitors, inhibits, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Acetyl-calpastatin184-210, (human), Tocris Bioscience, Calpain Inhibitor products

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