BAPTA AM

Cat. No. 2787

BAPTA AM C34H40N2O18 [126150-97-8]

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Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)

Biological Activity

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.

Technical Data

M.Wt:
764.68
Formula:
C34H40N2O18
Solubility:
Soluble to 30 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
126150-97-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Tang et al (2007) The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Biochem.Pharmacol. 74 1596. PMID: 17826747.

Heilporn et al (1994) Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin. Bull.Soc.Chim.Belg. 103 309.

Raspe et al (1989) Enhanced release of prostacyclin from quin 2-loaded endothelial cells. Eur.J.Pharmacol. 163 345. PMID: 2498111.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BAPTA AM include:

Ahn et al (2015) Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia. J Biol Chem 15 202. PMID: 26122524.

Azab et al (2015) Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane. J Biol Chem 6. PMID: 26489864.

Chen et al (2015) Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium. BMC Complement Altern Med 5 18204. PMID: 26659126.

Díaz et al (2015) Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med 212 665. PMID: 25870199.

Draganov et al (2015) Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Nature 5 16222. PMID: 26552848.

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. Sci Rep 125 1215. PMID: 25664854.

Morais et al (2015) L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis. PLoS One 10 e0132569. PMID: 26193352.

Pecze et al (2015) Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. MBio 290 28214. PMID: 26396196.

Pozner et al (2015) Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse. Front Mol Neurosci 8 12. PMID: 26005403.

Wang et al (2015) MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. Mol Pharmacol 290 168. PMID: 25416777.

Campwala et al (2014) P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci 127 4964. PMID: 25271060.

Pandya and Pillai (2014) TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis. Sci Rep 12 47. PMID: 25052836.

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265. PMID: 23235155.

Kajiya et al (2012) Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. J Clin Biochem Nutr 82 115. PMID: 22511543.

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. J Clin Invest 492 123. PMID: 23143333.

Do you know of a great paper that uses BAPTA AM from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: BAPTA AM, supplier, Cell-permeable, Ca2+, chelator, hERG, KV11.1, hKv13, hKv15, channels, blockers, Calcium, Signaling, Signalling, Agents, General, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, BAPTAAM, Tocris Bioscience, Biochemicals and Molecular Biology products

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