Cat. No. 2787

BAPTA AM C34H40N2O18 [126150-97-8]

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Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)

Biological Activity

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hKv1.5, hKV11.1 (hERG) and hKv1.3 channels (Ki values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.

Technical Data

Soluble to 30 mM in DMSO
>95 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Tang et al (2007) The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Biochem.Pharmacol. 74 1596. PMID: 17826747.

Heilporn et al (1994) Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin. Bull.Soc.Chim.Belg. 103 309.

Raspe et al (1989) Enhanced release of prostacyclin from quin 2-loaded endothelial cells. Eur.J.Pharmacol. 163 345. PMID: 2498111.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BAPTA AM include:

Díaz et al (2015) Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med 212 665. PMID: 25870199.

Morais et al (2015) L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis. PLoS One 10 e0132569. PMID: 26193352.

Pozner et al (2015) Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse. Front Mol Neurosci 8 12. PMID: 26005403.

Campwala et al (2014) P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci 127 4964. PMID: 25271060.

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265. PMID: 23235155.

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Keywords: BAPTA AM, supplier, Cell-permeable, Ca2+, chelator, hERG, KV11.1, hKv13, hKv15, channels, blockers, Calcium, Signaling, Signalling, Agents, General, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, BAPTAAM, Tocris Bioscience, Biochemicals and Molecular Biology products

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