EGTA

Cat. No. 2807

EGTA C14H24N2O10 [67-42-5]

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Chemical Name: Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid

Biological Activity

Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.

Technical Data

M.Wt:
380.35
Formula:
C14H24N2O10
Solubility:
Soluble to 100 mM in 1M NaOH
Storage:
Store at RT
CAS No:
67-42-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fisher et al (2004) Catalytic superoxide scavenging by metal complexes of the calcium chelator EGTA and contrast agent EHPG. Biochem.Biophy.Res.Comms. 323 163.

Boullerne et al (2001) Role of calcium in nitric oxide-induced cytotoxicity: EGTA protects mouse oligodendrocytes. J.Neurosci.Res. 63 124. PMID: 11169622.

If you know of a relevant reference for EGTA please let us know.

Citations are publications that use Tocris products. Selected citations for EGTA include:

Ahn et al (2015) Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia. Carcinogenesis 15 202. PMID: 26122524.

Shambharkar et al (2015) TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. BMC Complement Altern Med 10 e0127480. PMID: 25996873.

Chang et al (2013) Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. PLoS One 34 1096. PMID: 23349021.

Do you know of a great paper that uses EGTA from Tocris? If so please let us know.

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Keywords: EGTA, supplier, Calcium, chelating, agent, Reagents, Signaling, Signalling, Agents, General, Ca2+, Tocris Bioscience, Biochemicals and Molecular Biology products

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