Cat. No. 6176
Alternative Names: Fingolimod, Gilenya
Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]p
Biological ActivityS1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hopkins et al (2011) ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720). ACS Chem. Neurosci. 2 116. PMID: 22778861.
Brinkmann et al (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9 883. PMID: 21031003.
Coelho et al (2007) The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J.Pharmacol.Exp.Ther. 323 626. PMID: 17726159.
Shiow et al (2006) CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440 540. PMID: 16525420.
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Keywords: FTY 720, supplier, FTY720, |, Fingolimod, |, Gilenya, S1P, receptors, agonists, sphingosine-1-phosphate, immunosuppresent, sequesters, lymphocytes, orally, bioavailable, BBB, blood-brain, barrier, permeable, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products
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