NFPS

Cat. No. 2789

NFPS C24H24FNO3 [405225-21-0]

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Alternative Name: (±)-NFPS

Chemical Name: N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine

Biological Activity

Selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and  56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.

Technical Data

M.Wt:
393.45
Formula:
C24H24FNO3
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
405225-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Harsing Jr. et al (2003) The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacol.Biochem.Behav. 74 881.

Mallorga et al (2003) Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology 45 585. PMID: 12941372.

Bergeron et al (1998) Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proc.Natl.Acad.Sci.USA 95 15730.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for NFPS include:

Romei et al (2016) Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission. Brain Research Bulletin 127 100. PMID: 27565422.

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Keywords: NFPS, supplier, Selective, non-transportable, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, Glycine Transporter Inhibitor products

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Org 24598

Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).

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