NFPS

Cat. No. 2789

NFPS C24H24FNO3 [405225-21-0]

Price and Availability

For NFPS pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: (±)-NFPS

Chemical Name: N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine

Biological Activity

Selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and  56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.

Technical Data

M.Wt:
393.45
Formula:
C24H24FNO3
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
405225-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Harsing Jr. et al (2003) The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacol.Biochem.Behav. 74 881.

Mallorga et al (2003) Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology 45 585. PMID: 12941372.

Bergeron et al (1998) Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proc.Natl.Acad.Sci.USA 95 15730.

If you know of a relevant reference for NFPS please let us know.

Citations are publications that use Tocris products. Selected citations for NFPS include:

Romei et al (2016) Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission. Brain Research Bulletin 127 100. PMID: 27565422.

Do you know of a great paper that uses NFPS from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: NFPS, supplier, Selective, non-transportable, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, Glycine Transporter Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Schizophrenia Life Science Poster

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

New Products in this Area

(R)-Modafinil

Dopamine uptake inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11