Cat. No. 2802
Alternative Name: Agatoxin IVB
Biological ActivitySelective blocker of CaV2.1 P/Q-type calcium channels.
(Modifications: Disulfide bridge between 4 - 20, 12 - 25, 19 - 36, 27 - 34)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Barral et al (2001) High-affinity inhibition of glutamate release from corticostriatal synapses by ω-agatoxin TK. Eur.J.Pharmacol. 430 167. PMID: 11711028.
Teramoto et al (1997) A novel type of calcium channel sensitive to ω-agatoxin-TK in cultured rat cerebral cortical neurons. Brain Res. 756 225. PMID: 9187336.
Teramoto et al (1993) A novel peptide from funnel web spider venom, ω-Aga-TK, selectively blocks P-type calcium channels. Biochem.Biophys.Res.Comms. 196 134.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for ω-Agatoxin TK include:
Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606. PMID: 20826795.
Do you know of a great paper that uses ω-Agatoxin TK from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: w-Agatoxin TK, supplier, Ca2+, channel, blockers, P/Q-type, Calcium, CaV, Channels, P-Type, voltage-gated, voltage-dependent, Omega-Agatoxin, ω-Agatoxin, TK, w-AgatoxinTK, AgatoxinIVB, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products