Caffeine

Cat. No. 2793

Caffeine C8H10N4O2 [58-08-2]

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Chemical Name: 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Biological Activity

Central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.

Technical Data

M.Wt:
194.19
Formula:
C8H10N4O2
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
58-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Chen et al (2008) Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J.Neuroinflammation 5 12. PMID: 18387175.

Fisone et al (2004) Caffeine as a psychomotor stimulant: mechanism of action. Cell.Mol.Life Sci. 61 857. PMID: 15095008.

Nehlig et al (1992) Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res.Brain Res.Rev. 17 139. PMID: 1356551.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Caffeine include:

Okita et al (2015) Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells. PLoS One 10 e0139809. PMID: 26439264.

Do you know of a great paper that uses Caffeine from Tocris? If so please let us know.

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Keywords: Caffeine, supplier, A1, A2B, antagonists, CNS, stimulant, cyclic, nucleotide, PDE, inhibitors, inhibits, non-selective, adenosines, receptors, phosphodiesterases, ryanodine, receptors, Tocris Bioscience, Non-selective Adenosine Antagonist products

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