AG 045572

Cat. No. 2730

AG 045572 C30H37NO5 [263847-55-8]

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Chemical Name: 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide

Biological Activity

Selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo.

Technical Data

M.Wt:
491.62
Formula:
C30H37NO5
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>97 %
Storage:
Store at RT
CAS No:
263847-55-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Anderes et al (2003) Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats. J.Pharmacol.Exp.Ther. 305 688. PMID: 12606616.

Iatsimirskaia et al (2002) Effect of testosterone suppression on the pharmacokinetics of a potent GnRH receptor antagonist. Pharm.Res. 19 202. PMID: 11883648.

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Keywords: AG 045572, supplier, Selective, GnRH, receptor, antagonists, Receptors, Gonadotrophin-Releasing, Hormone, AG045572, gonadotropin, Tocris Bioscience, Gonadotropin-Releasing Hormone Receptor Antagonist products

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