Cat. No. 2730
Chemical Name: 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pen
Biological ActivitySelective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Anderes et al (2003) Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats. J.Pharmacol.Exp.Ther. 305 688. PMID: 12606616.
Iatsimirskaia et al (2002) Effect of testosterone suppression on the pharmacokinetics of a potent GnRH receptor antagonist. Pharm.Res. 19 202. PMID: 11883648.
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Keywords: AG 045572, supplier, Selective, GnRH, receptor, antagonists, Receptors, Gonadotrophin-Releasing, Hormone, AG045572, gonadotropin, Tocris Bioscience, Gonadotropin-Releasing Hormone Receptor Antagonist products
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