Cat. No. 2778
Chemical Name: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(
Biological ActivityNon-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Specio et al (2008) CRF1 receptor antagonists attenuate ascalated cocaine self-administration in rats. Psychopharmacol. 196 473.
Zorrilla et al (2002) Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 952 188. PMID: 12376179.
Webster et al (1996) In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 137 5747. PMID: 8940412.
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Citations are publications that use Tocris products. Selected citations for Antalarmin hydrochloride include:
Gray et al (2015) Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. J Neurosci 35 3879. PMID: 25740517.
Wood et al (2006) Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats. Neuropsychopharmacology 31 2580. PMID: 16710322.
Do you know of a great paper that uses Antalarmin hydrochloride from Tocris? If so please let us know.
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Keywords: Antalarmin hydrochloride, supplier, CRF1, antagonists, Corticotropin-Releasing, Factor1, Receptors, Tocris Bioscience, CRF1 Receptor Antagonist products
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