M 344

Cat. No. 2771

M 344 C16H25N3O3 [251456-60-7]

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Chemical Name: 4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

Biological Activity

Histone deacetylase inhibitor (IC50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.

Technical Data

M.Wt:
307.39
Formula:
C16H25N3O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
251456-60-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Riessland et al (2006) The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. Hum.Genet. 120 101. PMID: 16724231.

Takai et al (2006) M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol.Oncol. 101 108. PMID: 16263156.

Jung et al (1999) Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J.Med.Chem. 42 4669. PMID: 10579829.

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Keywords: M 344, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, M344, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products

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