Cat. No. 2770
Alternative Name: PhTx-74
Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]hepty
Biological ActivityAMPA receptor antagonist. Non-selective homomeric GluR3 and GluR1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluR3 and GluR1 with a 100-fold greater potency than heteromeric GluR1/2 and GluR2/3 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Poulsen et al (2013) Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol.Pharmacol. 85 261. PMID: 24220009.
Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 129 4902. PMID: 17391037.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Philanthotoxin 74 include:
Kim and Ziff (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol 12 e1001900. PMID: 24983627.
Do you know of a great paper that uses Philanthotoxin 74 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Philanthotoxin 74, supplier, GluR1/2, selective, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, Philanthotoxin74, PhTx74, homomeric, GluR3, GluR1, GluR2/3, Tocris Bioscience, AMPA Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent NMDA receptor antagonist; NR2A selectivecis-6-Hydroxynorketamine hydrochloride
Metabolite of ketamine (Cat.No. 3131); antidepressive
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.