Philanthotoxin 74

Cat. No. 2770

Philanthotoxin 74 C24H42N4O3.2HCl [1227301-51-0]

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Alternative Name: PhTx-74

Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride

Biological Activity

AMPA receptor antagonist. Non-selective homomeric GluR3 and GluR1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluR3 and GluR1 with a 100-fold greater potency than heteromeric GluR1/2 and GluR2/3 receptors.

Technical Data

M.Wt:
507.54
Formula:
C24H42N4O3.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1227301-51-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Poulsen et al (2013) Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol.Pharmacol. 85 261. PMID: 24220009.

Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 129 4902. PMID: 17391037.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Philanthotoxin 74 include:

Kim and Ziff (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol 12 e1001900. PMID: 24983627.

Do you know of a great paper that uses Philanthotoxin 74 from Tocris? If so please let us know.

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Keywords: Philanthotoxin 74, supplier, GluR1/2, selective, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, Philanthotoxin74, PhTx74, homomeric, GluR3, GluR1, GluR2/3, Tocris Bioscience, AMPA Receptor Antagonist products

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