BX 513 hydrochloride
Cat. No. 2769
Alternative Name: VUF 2274
Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-α,α-diph
Biological ActivitySelective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Casarosa et al (2003) Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor. J.Biol.Chem. 278 5172. PMID: 12456673.
Ng et al (1999) Discovery of a novel non-peptide CCR1 receptor antagonists. J.Med.Chem. 42 4680. PMID: 10579830.
Hesselgesser et al (1998) Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor. J.Biol.Chem. 273 15687. PMID: 9624164.
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