BX 513 hydrochloride

Cat. No. 2769

BX 513 hydrochloride C28H29ClN2O.HCl [1216540-18-9]

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Alternative Name: VUF 2274

Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride

Biological Activity

Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a  HCMV-encoded chemokine receptor.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Casarosa et al (2003) Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor. J.Biol.Chem. 278 5172. PMID: 12456673.

Ng et al (1999) Discovery of a novel non-peptide CCR1 receptor antagonists. J.Med.Chem. 42 4680. PMID: 10579830.

Hesselgesser et al (1998) Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor. J.Biol.Chem. 273 15687. PMID: 9624164.

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Citations are publications that use Tocris products.

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Keywords: BX 513 hydrochloride, supplier, Selective, CCR1, antagonists, chemokine, Receptors, BX513, hydrochloride, VUF2274, Rantes, Tocris Bioscience, Chemokine CC Receptor Antagonist products

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