Cat. No. 1590
Biological ActivityHighly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Calo et al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223. PMID: 11906488.
Rizzi et al (2002) [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 300 57. PMID: 11752097.
Okada et al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem.Biophys.Res.Commun. 278 493. PMID: 11097863.
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Citations are publications that use Tocris products. Selected citations for [Arg14,Lys15]Nociceptin include:
Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132. PMID: 14662736.
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Keywords: [Arg14,Lys15]-Nociceptin, supplier, potent, selective, NOP, agonists, Nociceptin, Receptors, ORL1, OP4, Opioid, Tocris Bioscience, NOP Receptor Agonist products
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