Cat. No. 2767
Chemical Name: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-
Biological ActivitySelective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chung et al (2009) Cholecystokinin action on layer 6b neurons in somatosensory cortex. Brain Res. 1282 10. PMID: 19497313.
Kees et al (1989) Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. J.Med.Chem. 32 13. PMID: 2909725.
Lotti and Chang (1989) A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. Eur.J.Pharmacol. 162 273. PMID: 2721567.
If you know of a relevant reference for L-365,260 please let us know.
Citations are publications that use Tocris products. Selected citations for L-365,260 include:
Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278. PMID: 24385417.
Do you know of a great paper that uses L-365,260 from Tocris? If so please let us know.
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Keywords: L-365,260, supplier, Selective, CCK2, antagonists, Cholecystokinin2, Receptors, L365260, Tocris Bioscience, CCK2 Receptor Antagonist products