L-365,260

Cat. No. 2767

L-365,260 C24H22N4O2 [118101-09-0]

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Chemical Name: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea

Biological Activity

Selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.

Technical Data

M.Wt:
398.46
Formula:
C24H22N4O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
118101-09-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Chung et al (2009) Cholecystokinin action on layer 6b neurons in somatosensory cortex. Brain Res. 1282 10. PMID: 19497313.

Kees et al (1989) Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. J.Med.Chem. 32 13. PMID: 2909725.

Lotti and Chang (1989) A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. Eur.J.Pharmacol. 162 273. PMID: 2721567.

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Citations are publications that use Tocris products. Selected citations for L-365,260 include:

Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278. PMID: 24385417.

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Keywords: L-365,260, supplier, Selective, CCK2, antagonists, Cholecystokinin2, Receptors, L365260, Tocris Bioscience, CCK2 Receptor Antagonist products

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