Cat. No. 2698
Alternative Name: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide
Biological ActivitySelective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists.
(Modifications: Ala-22 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 85 273. PMID: 16996122.
Sollenburg et al (2006) M871 - a novel peptide antagonist selectively recognizing the galanin receptor type 2. Int.J.Pept.Res.Ther. 12 115.
If you know of a relevant reference for M871 please let us know.
Citations are publications that use Tocris products. Selected citations for M871 include:
Zhang (2017) Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulatecortex of normal rats and rats with mononeuropathy Sci Rep 7 45930. PMID: 28378856.
Millón et al (2015) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Immun Inflamm Dis 18. PMID: 25522404.
Scanlon et al (2015) Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Int J Neuropsychopharmacol 6 6885. PMID: 25917569.
Millòn et al (2014) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Int.J.Neuropsychopharmacol. 18. PMID: 25522404.
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Keywords: M871, supplier, Selective, GAL2, GalR2, antagonists, Receptors, Galanin, Tocris Bioscience, Galanin Receptor Antagonist products
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