DCA

Cat. No. 2755

DCA C2HCl2NaO2 [2156-56-1]

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Chemical Name: Sodium dichloroacetate

Biological Activity

Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.

Technical Data

M.Wt:
150.92
Formula:
C2HCl2NaO2
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at RT
CAS No:
2156-56-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bonnet et al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11 37. PMID: 17222789.

Bowker-kinley et al (1998) Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem.J. 329 191. PMID: 9405293.

Stacpoole (1989) The pharmacology of dichloroacetate. Metabolism Clin.Exp. 38 1124.

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Citations are publications that use Tocris products.

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Keywords: DCA, supplier, Mitochondrial, pyruvate, dehydrogenase, kinase, PDK, inhibitors, inhibits, Kinases, Tocris Bioscience, Other Kinase Inhibitor products

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