Naspm trihydrochloride

Cat. No. 2766

Naspm trihydrochloride C22H34N4O.3HCl [1049731-36-3]

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Alternative Name: 1-Naphthyl acetyl spermine trihydrochloride

Chemical Name: N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride

Biological Activity

Selective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluR2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.

Technical Data

M.Wt:
479.91
Formula:
C22H34N4O.3HCl
Solubility:
Soluble to 100 mM in water
Purity:
>97 %
Storage:
Desiccate at +4°C
CAS No:
1049731-36-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 129 4902. PMID: 17391037.

Noh et al (2005) Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death. Proc.Natl.Acad.Sci.USA 102 12230.

Koike et al (1997) Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci.Res. 29 27. PMID: 9293490.

Tsubokawa et al (1995) Effects of spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischaemia. J.Neurophysiol. 74 218. PMID: 7472325.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Naspm trihydrochloride include:

Park et al (2016) Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. J Neurosci 36 622. PMID: 26758849.

Megill et al (2015) Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease. Nature 35 11346. PMID: 26269641.

Blanco-Suárez et al (2014) Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation. Nat Commun 34 1898. PMID: 25248834.

Fernandes et al (2014) In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons. PLoS One 9 e99958. PMID: 24960035.

Kim and Ziff (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol 12 e1001900. PMID: 24983627.

Lee et al (2014) Synapse elimination and learning rules co-regulated by MHC class I H2-Db. J Cereb Blood Flow Metab 509 195. PMID: 24695230.

Roy et al (2014) Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. J Neurosci 9 e101883. PMID: 25007337.

Cabañero et al (2013) Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord. Neuropsychopharmacology 38 1472. PMID: 23403695.

Jaafari et al (2012) PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking. J Neurosci 32 11618. PMID: 22915106.

Villers et al (2012) Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development. PLoS One 7 e40823. PMID: 22792408.

Do you know of a great paper that uses Naspm trihydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Naspm trihydrochloride, supplier, AMPA, receptors, antagonists, GluR2, calcium-permeable, Ca2+, ionotropic, glutamate, receptors, iGluR, Tocris Bioscience, AMPA Receptor Antagonist products

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