Radicicol

Cat. No. 1589

Radicicol C18H17ClO6 [12772-57-5]

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Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

Biological Activity

Antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

Technical Data

M.Wt:
364.78
Formula:
C18H17ClO6
Solubility:
Soluble to 25 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
12772-57-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lee et al (2002) Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 188 47. PMID: 11911945.

Schulte et al (1999) Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 13 1435. PMID: 10478836.

Oikawa et al (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 241 221. PMID: 7694864.

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Keywords: Radicicol, supplier, Hsp90, inhibitors, inhibits, Antifungal, antibiotics, Heat, Shock, Proteins, 90, Tocris Bioscience, Hsp90 Inhibitor products

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