TCS 401

Cat. No. 2754

TCS 401 C10H10N2O5S.HCl [243966-09-8]

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Chemical Name: 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride

Biological Activity

Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).

Technical Data

Soluble to 25 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Andersen et al (2002) Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J.Med.Chem. 45 4443. PMID: 12238924.

Iversen et al (2000) Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem. 275 10300. PMID: 10744717.

If you know of a relevant reference for TCS 401 please let us know.

Citations are publications that use Tocris products. Selected citations for TCS 401 include:

Du et al (2015) Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. J Neurosci 21 523. PMID: 25999679.

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Keywords: TCS 401, supplier, Selective, inhibitors, inhibits, PTP1B, Shp1, Shp2, Protein, Tyrosine, Phosphatases, TCS401, Tocris Bioscience, Protein Tyrosine Phosphatases Inhibitor products

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