Arachidonic acid (in Tocrisolve™100)
Cat. No. 2756
Chemical Name: 5Z,8Z,11Z,14Z-Eicosatetraenoic acid
Biological ActivityEndogenous free fatty acid released from phospholipids by phospholipase A2, in water-soluble emulsion (for details see TocrisolveTM 100, Cat. No. 1684). Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Higuchi et al (2007) Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12-lipoxygenase activation in glioma cells. Life Sci. 80 1856. PMID: 17400255.
Levick et al (2007) Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation. J.Immunol. 178 641. PMID: 17202322.
Nakanishi et al (2006) Roles of cPLA2α and arachidonic acid in cancer. Biochim.Biophys.Acta 1761 1335. PMID: 17052951.
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Keywords: Arachidonic acid (in Tocrisolve 100), supplier, Endogenous, free, fatty, acid, water-soluble, emulsion, Lipid, Metabolism, Prostanoid, eicosanoid, receptors, leukotrienes, eicosanoids, prostaglandins, prostacyclins, Tocris Bioscience, Other Lipid Metabolism products