NNC 05-2090 hydrochloride

Cat. No. 2747

NNC 05-2090 hydrochloride C27H30N2O2.HCl [184845-18-9]

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Chemical Name: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride

Biological Activity

GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).

Technical Data

M.Wt:
451.01
Formula:
C27H30N2O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 13 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
184845-18-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Dalby et al (1997) Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 28 51. PMID: 9255599.

Thomsen et al (1997) 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br.J.Pharmacol. 120 983. PMID: 9134205.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for NNC 05-2090 hydrochloride include:

Wang et al (2015) Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Sleep 9 188. PMID: 26041994.

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Keywords: NNC 05-2090 hydrochloride, supplier, GABA, reuptake, inhibitors, inhibits, moderately, BGT-1, selective, Transporters, Monoamine, Neurotransmitter, NNC052090, hydrochloride, Tocris Bioscience, GABA Inhibitor products

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