NNC 05-2090 hydrochloride
Cat. No. 2747
Chemical Name: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2
Biological ActivityGABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Dalby et al (1997) Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 28 51. PMID: 9255599.
Thomsen et al (1997) 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br.J.Pharmacol. 120 983. PMID: 9134205.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for NNC 05-2090 hydrochloride include:
Wang et al (2015) Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Sleep 9 188. PMID: 26041994.
Do you know of a great paper that uses NNC 05-2090 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NNC 05-2090 hydrochloride, supplier, GABA, reuptake, inhibitors, inhibits, moderately, BGT-1, selective, Transporters, Monoamine, Neurotransmitter, NNC052090, hydrochloride, Tocris Bioscience, GABA Inhibitor products
Find multiple products by catalog number
New Products in this Area
Dopamine uptake inhibitorOrg 24598
Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.