Cat. No. 2738
Chemical Name: (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-mo
Biological ActivityPositive allosteric modulator and at higher concentrations direct agonist of GABAA receptors (EC50 = 1.1 μM). Also displays positive modulation of glycine receptors (EC50 = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Weir et al (2004) The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. Br.J.Anaesth. 92 704. PMID: 15033889.
Visser et al (2002) Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo. J.Pharmacol.Exp.Ther. 303 616. PMID: 12388643.
Hill-Venning et al (1996) The anaesthetic action and modulaton of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology 35 1209. PMID: 9014136.
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Keywords: Org 20599, supplier, Positive, allosteric, modulators, direct, agonists, GABAA, receptors, Receptors, Org20599, Tocris Bioscience, GABAA Receptor Modulator products