Cat. No. 2738
Chemical Name: (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-mo
Biological ActivityPositive allosteric modulator and at higher concentrations direct agonist of GABAA receptors (EC50 = 1.1 μM). Also displays positive modulation of glycine receptors (EC50 = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Weir et al (2004) The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. Br.J.Anaesth. 92 704. PMID: 15033889.
Visser et al (2002) Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo. J.Pharmacol.Exp.Ther. 303 616. PMID: 12388643.
Hill-Venning et al (1996) The anaesthetic action and modulaton of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology 35 1209. PMID: 9014136.
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Keywords: Org 20599, supplier, Positive, allosteric, modulators, direct, agonists, GABAA, receptors, Receptors, Org20599, Tocris Bioscience, GABAA Receptor Modulator products
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November 8 - 10, 2017