Cat. No. 2722
Alternative Name: Chromogranin A344-364
Biological ActivityNon-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kruger et al (2003) Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul.Peptides 114 29.
Mahata et al (2000) Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity. Mol.Endocrinol. 14 1525. PMID: 11043569.
Mahata et al (1997) Novel autocrine feedback control of catecholamine release. J.Clin.Invest. 100 1623. PMID: 9294131.
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Keywords: Catestatin, supplier, Non-competitive, nicotinic, cholinergic, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Chromogranin, A344-364, A344364, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products
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April 1 - 5, 2017
Washington, D.C., USA