LDN 212854

Cat. No. 6151new

LDN 212854 C25H22N6 [1432597-26-6]

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Chemical Name: 5-(6-(4-(1-Piperazinyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

Biological Activity

Potent ALK inhibitor (IC50 values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Exhibits selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Inhibits heterotopic ossification in a mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC50 values < 100 nM).

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patent 14/776,302

Technical Data

M.Wt:
406.48
Formula:
C25H22N6
Solubility:
Soluble to 50 mM in 2eq.HCl
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1432597-26-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mohedas et al (2013) Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 8 1291. PMID: 23547776.

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Keywords: LDN 212854, supplier, LDN212854, ALK, inhibitors, inhibits, potent, in, vivo, active, BMP1, ALK2, bone, morphogenetic, protein, type, I, Tocris Bioscience, BMP and Other Activin Receptor Inhibitor products

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