Cat. No. 2715
Alternative Name: 3-Phenacyl UDP disodium salt
Chemical Name: 3-(2-Oxo-2-phenylethyl)-uridine-5'-d
Biological ActivityPotent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mitchell et al (2012) Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J.Pharmacol.Exp.Ther. 343 755. PMID: 22991416.
El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076. PMID: 17125260.
If you know of a relevant reference for PSB 0474 please let us know.
Citations are publications that use Tocris products. Selected citations for PSB 0474 include:
Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29. PMID: 24886406.
Quintas et al (2014) Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation 11 141. PMID: 25178395.
Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Exp Eye Res 9 31. PMID: 22825617.
Kataoka et al (2011) Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways. Purinergic Signal 7 403. PMID: 21567128.
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Keywords: PSB 0474, supplier, Potent, selective, P2Y6, agonists, Receptors, Purinergic, purinoceptors, PSB0474, Tocris Bioscience, Purinergic (P2Y) Receptor Agonist products
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