PSB 0474

Cat. No. 2715

PSB 0474 C17H18N2Na2O13P2 [917567-60-3]

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Alternative Name: 3-Phenacyl UDP disodium salt

Chemical Name: 3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphate disodium salt

Biological Activity

Potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.

Technical Data

M.Wt:
566.26
Formula:
C17H18N2Na2O13P2
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
917567-60-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Mitchell et al (2012) Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J.Pharmacol.Exp.Ther. 343 755. PMID: 22991416.

El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076. PMID: 17125260.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PSB 0474 include:

Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29. PMID: 24886406.

Quintas et al (2014) Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation 11 141. PMID: 25178395.

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View Related Products by Product Action

Keywords: PSB 0474, supplier, Potent, selective, P2Y6, agonists, Receptors, Purinergic, purinoceptors, PSB0474, Tocris Bioscience, Purinergic (P2Y) Receptor Agonist products

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