Cat. No. 1588
Alternative Name: Lu 19-005
Chemical Name: (1R,3S)-rel-3-(3,4-Dichlorophenyl)-
Biological ActivityPotent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET) (Ki values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Gu et al (2000) Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 43 4868. PMID: 11123996.
Negus et al (1999) Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 291 60. PMID: 10490887.
Hyttel and Larsen (1985) Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline and serotonin. J.Neurochem. 44 1615. PMID: 2580950.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Indatraline hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Indatraline hydrochloride, supplier, Potent, noradrenalin, noradrenaline, reuptake, inhibitors, inhibits, 5-HT, dopamine, Noradrenalin, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, DAT, Dopamine, Serotonin, SERT, 5-Hydroxytryptamine, Lu19-005, Tocris Bioscience, 5-HT Transporter Inhibitor products