Fananserin

Cat. No. 2645

Fananserin C23H24FN3O2S [127625-29-0]

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Alternative Name: RP 62203

Chemical Name: 2-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphthyl[1,8-cd]isothiazole-1,1-dioxide

Biological Activity

5-HT2A receptor antagonist that also displays high affinity at D4 receptors (Ki values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT2A, D4, H1, α1, 5-HT1A and D2 receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT in vitro (IC50 = 7.76 nM) and antagonizes mescaline-induced head twitches in vivo.

Technical Data

M.Wt:
425.52
Formula:
C23H24FN3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
127625-29-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Heuillet et al (1996) The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor. Eur.J.Pharmacol. 314 229. PMID: 8957240.

Doble et al (1992) Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist. Br.J.Pharmacol. 105 27. PMID: 1596688.

Malleron et al (1991) Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. J.Med.Chem. 34 2477. PMID: 1908521.

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Keywords: Fananserin, supplier, 5-HT2A, antagonists, D4, Serotonin, Receptors, Dopamine, dopaminergic, RP62203, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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