Ro 32-0432 hydrochloride

Cat. No. 1587

Ro 32-0432 hydrochloride C28H28N4O2.HCl [151342-35-7]

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Chemical Name: 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride

Biological Activity

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.

Technical Data

M.Wt:
489.01
Formula:
C28H28N4O2.HCl
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
151342-35-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Birchall et al (1994) Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 268 922. PMID: 8114006.

Wilkinson et al (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 294 335. PMID: 8373348.

If you know of a relevant reference for Ro 32-0432 hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Ro 32-0432 hydrochloride include:

Signore et al (2014) Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis 5 e1223. PMID: 24810059.

Robert et al (2009) Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One 4 e7889. PMID: 19924252.

Do you know of a great paper that uses Ro 32-0432 hydrochloride from Tocris? If so please let us know.

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Keywords: Ro 32-0432 hydrochloride, supplier, Potent, orally, active, PKC, inhibitors, inhibits, Protein, Kinases, C, Ro32-0432, hydrochloride, Tocris Bioscience, Protein Kinase C Inhibitor products

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