BIBP 3226 trifluoroacetate

Cat. No. 2707

BIBP 3226 trifluoroacetate C27H31N5O3.2CF3CO2H

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Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide ditrifluoroacetate

Biological Activity

Mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Technical Data

M.Wt:
701.61
Formula:
C27H31N5O3.2CF3CO2H
Solubility:
Soluble to 10 mM in water with sonication and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fang et al (2006) In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 27 2207. PMID: 16762456.

Mollereau et al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1. PMID: 11325787.

Kask et al (1996) Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur.J.Pharmacol. 317 R3. PMID: 8997632.

If you know of a relevant reference for BIBP 3226 trifluoroacetate please let us know.

Citations are publications that use Tocris products. Selected citations for BIBP 3226 trifluoroacetate include:

Aveleira et al (2015) Neuropeptide Y stimulates autophagy in hypothalamic neurons. Cell Death Dis 112 E1642. PMID: 25775546.

Martins et al (2015) Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro 7. PMID: 26311075.

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545. PMID: 25751534.

Reidelberger et al (2013) Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab 304 E944. PMID: 23482449.

Santos-Carvalho et al (2013) Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Proc Natl Acad Sci U S A 4 e636. PMID: 23681231.

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969. PMID: 23776582.

Novielli et al (2012) Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats. PLoS One 7 e46659. PMID: 23071607.

Pleil et al (2012) Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology 62 1777. PMID: 22182779.

Sparrow et al (2012) Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Proc Natl Acad Sci U S A 37 1409. PMID: 22218088.

Yi et al (2012) Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes 61 339. PMID: 22210324.

Do you know of a great paper that uses BIBP 3226 trifluoroacetate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: BIBP 3226 trifluoroacetate, supplier, Mixed, NPFF, NPY, Y1, receptor, antagonists, Receptors, Neuropeptide, FF/AF, Y, BIBP3226, trifluoroacetate, npffr1, npffr2, npff1, npff2, neuropeptides, Tocris Bioscience, NPY Receptor Antagonist products

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