YM 90K hydrochloride
Cat. No. 2701
Chemical Name: 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-
Biological ActivitySelective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration.
Licensing InformationSold with the permission of Astellas Pharma Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nakano et al (2001) A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils. Life Sci. 69 1983. PMID: 11589513.
Umemura et al (1997) Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia. Brain Res. 773 61. PMID: 9409705.
Ohmori et al (1994) 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. J.Med.Chem. 37 467. PMID: 8120865.
If you know of a relevant reference for YM 90K hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses YM 90K hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: YM 90K hydrochloride, supplier, Selective, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, YM90K, hydrochloride, Tocris Bioscience, AMPA Receptor Antagonist products