AR-M 1896

Cat. No. 2699

AR-M 1896 Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-NH2

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Alternative Name: Gal(2-11)amide

Biological Activity

Selective galanin GAL2 receptor agonist (IC50 values are 1.76 and 879 nM for GAL2 and GAL1 respectively). Also shows moderate affinity for GAL3 receptors (Ki values are 88 and 271 nM for GAL2 and GAL3 respectively). Antiepileptogenic agent; prevents full seizures and postkindling increases in hippocampal excitability.

Technical Data

M.Wt:
1136.31
Formula:
C54H81N13O14
Sequence:
WTLNSAGYLL

(Modifications: Leu-10 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 20% formic acid
Storage:
Desiccate at -20°C
CAS No:
367518-31-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700. PMID: 16699066.

Lu et al (2005) Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides 39 165. PMID: 15944007.

Liu et al (2001) Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc.Natl.Acad.Sci USA 98 9960.

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Keywords: AR-M 1896, supplier, Selective, GAL2, GalR2, agonists, Receptors, Galanin, ARM1896, Tocris Bioscience, Galanin Receptor Agonist products

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