Dexfenfluramine hydrochloride

Cat. No. 2695

Dexfenfluramine hydrochloride C12H16F3N.HCl [3239-45-0]

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Alternative Name: (+)-Fenfluramine

Chemical Name: (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride

Biological Activity

Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.

Technical Data

M.Wt:
267.72
Formula:
C12H16F3N.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at RT
CAS No:
3239-45-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bush et al (2006) Chronic treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced obese mice. Endocrine 29 375. PMID: 16785615.

Higgins et al (2001) Influence of the 5-HT2C receptor antagonist SB242,084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. Br.J.Pharmacol. 133 459. PMID: 11399662.

Caccia et al (1997) Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluoxetine. Pharmacol.Biochem.Behav. 57 851. PMID: 9259015.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Dexfenfluramine hydrochloride include:

Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392. PMID: 27413150.

Kiyasova et al (2011) A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei. J Neurosci 31 2756. PMID: 21414898.

Do you know of a great paper that uses Dexfenfluramine hydrochloride from Tocris? If so please let us know.

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Keywords: Dexfenfluramine hydrochloride, supplier, 5-HT, reuptake, inhibitors, inhibits, stimulates, release, Serotonin, 5-Hydroxytryptamine, Receptors, Transporters, SERT, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products

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