HDS 029

Cat. No. 2646

HDS 029 C17H11ClFN5O [881001-19-0]

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Chemical Name: N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide

Biological Activity

Potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).

Technical Data

M.Wt:
355.76
Formula:
C17H11ClFN5O
Solubility:
Soluble to 25 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
881001-19-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Klutchko et al (2006) Tyrosine kinase inhibitors. 19. 6-alkynamides of 4-anilinoquinazolines and 4-aniliopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J.Med.Chem. 49 1475. PMID: 16480284.

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Citations are publications that use Tocris products. Selected citations for HDS 029 include:

Watanabe et al (2011) A novel glycosylation signal regulates transforming growth factor beta receptors as evidenced by endo-beta-galactosidase C expression in rodent cells. Glycobiology 21 482. PMID: 21062784.

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Keywords: HDS 029, supplier, Potent, inhibitors, inhibits, ErbB, receptor, family, Epidermal, Growth, Factors, Receptors, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, HDS029, Tocris Bioscience, EGFR Inhibitor products

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